ThanEver Inc., Daedeok Innopolis
ThanEver Inc., Daedeok Innopolis
rPENs-I™:
Introducing the ultimate stealth vector from the nature.
Made by the rose bud to carry what matters and pass unseen. Now ready for your formula.
Made by ThanEver Institute for Regenerative Science
01 SOURCE
Not Just Rose Petal, Medicinal Icewing Whole Rose Bud
Harvested whole, before the bud opens, from Icewing, a protected rose variety. Every vesicle comes from the living plant, not a cell culture.
02 MARK
01 SOURCE
62nm
Not Just Rose Petal, Medicinal Icewing Whole Rose Bud
Harvested whole, before the bud opens, from Icewing, a protected rose variety. Every vesicle comes from the living plant, not a cell culture.
01 The Size
Non-artificial, Naturally Encapsulated Bioactives
Sealed in the rose’s own membrane at 69 nm. No synthetic liposome, no added carrier, no fragility.
01 The Size
02 THE SIZE
69 nm MODE Small and Uniform
Non-artificial, Naturally Encapsulated Bioactives
Sealed in the rose’s own membrane at 69 nm. No synthetic liposome, no added carrier, no fragility.
03 The Definition
How to Define the Best Exosomes:
By the Uniform Quality Control
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PEAK (MODE) DIAMETER
69 nm
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MORPHOLOGY
Intact, membrane-bound vesicles
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MEAN DIAMETER
94 nm
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HIGHLIGHTED
Representative vesicles
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SPAN
0.89
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SCALE BAR
100 nm
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METHOD
TRPS (Tunable Resistive Pulse Sensing)
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METHOD
Transmission electron microscopy
04 REPORT
0.00 Non-Irritant
Tested in a 24-hour human patch test by the Korea Dermatology Research Institute. Not a single reaction was recorded.
04 REPORT
The day returns at nine
0.00 Non-Irritant
Tested in a 24-hour human patch test by the Korea Dermatology Research Institute. Not a single reaction was recorded.
PRICING
$3,750 Value Free Sample,
or Life-time 5 T Particles for $2,000
Test 100 billion particles in your own formula at no cost. When you are ready, one vial delivers 5 trillion particles, enough for 50 ampoules at 100 billion each.
100B Particles (Free Sample)
Test it in your own formula before you order.
SAMPLE
$0 (USD)
Part of the Rose /
Not petals, hips, etc., Whole Rose Bud Exosome
Number of Particles /
100B (1 ×10¹¹)
Particle Size /
Mode 69 nm, Mean 94 nm
Format /
Lyophilized powder, no cold chain
Shipping /
Free Shipping and Refund Worldwide
rPENs-I™ Free Sample
100B Particles (Free Sample)
Test it in your own formula before you order.
SAMPLE
$0 (USD)
Part of the Rose /
Not petals, hips, etc., Whole Rose Bud Exosome
Number of Particles /
100B (1 ×10¹¹)
Particle Size /
Mode 69 nm, Mean 94 nm
Format /
Lyophilized powder, no cold chain
Shipping /
Free Shipping and Refund Worldwide
rPENs-I™ Free Sample
100B Particles (Free Sample)
Test it in your own formula before you order.
SAMPLE
$0 (USD)
Part of the Rose /
Not petals, hips, etc., Whole Rose Bud Exosome
Number of Particles /
100B (1 ×10¹¹)
Particle Size /
Mode 69 nm, Mean 94 nm
Format /
Lyophilized powder, no cold chain
Shipping /
Free Shipping and Refund Worldwide
rPENs-I™ Free Sample
rPENs-I 5 Trillion Particles Exosomes
Enough for 50 ampoules at 100 billion particles each.
Tester
$2000 (USD)
Part of the Rose /
Not petals, hips, etc., Whole Rose Bud Exosome
Number of Particles /
5T (5 ×10¹²)
Particle Size /
Mode 69 nm, Mean 94 nm
Format /
Lyophilized powder, no cold chain
Shipping /
Free Shipping and Refund Worldwide
rPENs-I 5 Trillion Particles Exosomes
Enough for 50 ampoules at 100 billion particles each.
Tester
$2000 (USD)
Part of the Rose /
Not petals, hips, etc., Whole Rose Bud Exosome
Number of Particles /
5T (5 ×10¹²)
Particle Size /
Mode 69 nm, Mean 94 nm
Format /
Lyophilized powder, no cold chain
Shipping /
Free Shipping and Refund Worldwide
rPENs-I 5 Trillion Particles Exosomes
Enough for 50 ampoules at 100 billion particles each.
Tester
$2000 (USD)
Part of the Rose /
Not petals, hips, etc., Whole Rose Bud Exosome
Number of Particles /
5T (5 ×10¹²)
Particle Size /
Mode 69 nm, Mean 94 nm
Format /
Lyophilized powder, no cold chain
Shipping /
Free Shipping and Refund Worldwide
Company
TIRS
ThanEver Institute of Regenerative Science
TIRS builds on 40 years of research and is based in the Daejeon Bio Venture Town, Daedeok Innopolis research cluster. Our technology began as gene-loaded cell therapy for intractable neurological
diseases. We are now commercializing it
for anti-aging applications.
ThanEver Inc.
Suite 301, Daejeon Bio Venture Town, 1662 Yuseong-daero, Yuseong-gu, Daejeon, Republic of Korea
QUESTIONS
Before you order
Everything you need to know before your first order. Full specifications are in the TDS.
Still unsure — write to us and a person answers
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01
Can I get a sample?
Yes. We provide a free 100-billion-particle sample to cosmetic businesses, and shipping is also free of charge. To request a sample, please complete the sample request form or email us at sales@thanever.com with your company name and country. Each request is reviewed to confirm business details before the sample is shipped.
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01
Can I get a sample?
Yes. We provide a free 100-billion-particle sample to cosmetic businesses, and shipping is also free of charge. To request a sample, please complete the sample request form or email us at sales@thanever.com with your company name and country. Each request is reviewed to confirm business details before the sample is shipped.
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02
What is the MOQ and lead time?
There is no minimum order quantity. Orders can be placed from a single vial. In-stock orders are dispatched within five business days of order confirmation. If the product is out of stock, please allow one to two weeks for production. Shipping time is additional and varies by destination. For orders of 10 vials or more, please contact us at sales@thanever.com.
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02
What is the MOQ and lead time?
There is no minimum order quantity. Orders can be placed from a single vial. In-stock orders are dispatched within five business days of order confirmation. If the product is out of stock, please allow one to two weeks for production. Shipping time is additional and varies by destination. For orders of 10 vials or more, please contact us at sales@thanever.com.
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03
How many 100-billion ampoules can one vial make?
Fifty. Each vial contains 5 × 10¹² particles, which is enough for 50 ampoules at 100 billion particles each. Most exosome skincare products on the market list 1 to 10 billion particles per product. At that level, a single vial supplies 500 to 5,000 finished products.
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03
How many 100-billion ampoules can one vial make?
Fifty. Each vial contains 5 × 10¹² particles, which is enough for 50 ampoules at 100 billion particles each. Most exosome skincare products on the market list 1 to 10 billion particles per product. At that level, a single vial supplies 500 to 5,000 finished products.
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04
Are these exosomes? How are they different from EVs?
rPENs-I™ consists of plant-derived extracellular vesicles (EVs) isolated from whole rose buds. “Exosome” is the name most of the skincare market uses for this category. Scientifically, extracellular vesicles (EVs) is the umbrella term for lipid-bilayer particles released by cells. Exosomes are one subtype of EVs, defined by their origin inside the cell (the endosomal pathway). Because that origin cannot be confirmed by size alone, the international guideline MISEV2023 recommends the term EV unless it is demonstrated. That is why our INCI name reads Rosa Icewing Bud Extracellular Vesicles. By size, rPENs-I™ sits in the small-EV range. More than half of its particles are under 100 nm (d50 84 nm), and 90% are under 139 nm (d90), measured by TRPS.
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04
Are these exosomes? How are they different from EVs?
rPENs-I™ consists of plant-derived extracellular vesicles (EVs) isolated from whole rose buds. “Exosome” is the name most of the skincare market uses for this category. Scientifically, extracellular vesicles (EVs) is the umbrella term for lipid-bilayer particles released by cells. Exosomes are one subtype of EVs, defined by their origin inside the cell (the endosomal pathway). Because that origin cannot be confirmed by size alone, the international guideline MISEV2023 recommends the term EV unless it is demonstrated. That is why our INCI name reads Rosa Icewing Bud Extracellular Vesicles. By size, rPENs-I™ sits in the small-EV range. More than half of its particles are under 100 nm (d50 84 nm), and 90% are under 139 nm (d90), measured by TRPS.
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05
How do I reconstitute and formulate it?
Dissolve the lyophilized powder in ThanEver Diluent, then dilute to the particle concentration your formula requires. Each vial comes with one 300 mL bottle of ThanEver Diluent free of charge, and additional diluent is available for purchase. When a full vial is reconstituted in 300 mL, the solution contains about 1.7 × 10¹⁰ particles per mL. For example, 6 mL of this solution delivers 100 billion particles. Add the solution to the water phase during the cooling step, once the temperature is at or below 40°C. The recommended pH range is 4 to 7.
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05
How do I reconstitute and formulate it?
Dissolve the lyophilized powder in ThanEver Diluent, then dilute to the particle concentration your formula requires. Each vial comes with one 300 mL bottle of ThanEver Diluent free of charge, and additional diluent is available for purchase. When a full vial is reconstituted in 300 mL, the solution contains about 1.7 × 10¹⁰ particles per mL. For example, 6 mL of this solution delivers 100 billion particles. Add the solution to the water phase during the cooling step, once the temperature is at or below 40°C. The recommended pH range is 4 to 7.
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06
How should it be stored?
Store the unopened vial refrigerated at 2 to 8°C, tightly closed and protected from light. For long-term storage, keep it at −20°C or below. Keep it away from strong oxidizing agents, heat and humidity. Once reconstituted, use the solution promptly and do not refreeze it. As a lyophilized powder, rPENs-I™ ships without a cold chain and is classified as non-hazardous for transport under DOT and IATA.
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06
How should it be stored?
Store the unopened vial refrigerated at 2 to 8°C, tightly closed and protected from light. For long-term storage, keep it at −20°C or below. Keep it away from strong oxidizing agents, heat and humidity. Once reconstituted, use the solution promptly and do not refreeze it. As a lyophilized powder, rPENs-I™ ships without a cold chain and is classified as non-hazardous for transport under DOT and IATA.
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07
How is particle count verified?
Particle count is measured by both NTA (nanoparticle tracking analysis) and TRPS (tunable resistive pulse sensing). The specification of 5 × 10¹² particles per vial is based on TRPS (IZON). TRPS measures particles one by one as they pass through a nanopore. It calculates each particle’s size from the change in electrical current and the concentration from the particle flow rate. NTA estimates size and concentration by tracking the light scattered by moving particles.
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07
How is particle count verified?
Particle count is measured by both NTA (nanoparticle tracking analysis) and TRPS (tunable resistive pulse sensing). The specification of 5 × 10¹² particles per vial is based on TRPS (IZON). TRPS measures particles one by one as they pass through a nanopore. It calculates each particle’s size from the change in electrical current and the concentration from the particle flow rate. NTA estimates size and concentration by tracking the light scattered by moving particles.
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08
What is the INCI name?
The proposed INCI name is Rosa Icewing Bud Extracellular Vesicles, submitted to the Personal Care Products Council (PCPC) and currently under review. Ingredient labeling names differ by market. Please use the name required in your country of sale. In Korea, the ingredient is listed in the Korea Cosmetic Association ingredient dictionary under No. 24177.
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08
What is the INCI name?
The proposed INCI name is Rosa Icewing Bud Extracellular Vesicles, submitted to the Personal Care Products Council (PCPC) and currently under review. Ingredient labeling names differ by market. Please use the name required in your country of sale. In Korea, the ingredient is listed in the Korea Cosmetic Association ingredient dictionary under No. 24177.